A solutionenhanced dispersion by supercritical co2 seds was employed to prepare silk fibroin sf nanoparticles. Stanipharm supercritical fluid technology and facilities for the development and manufacturing of active pharmaceutical ingredients. Us6998051b2 particles from supercritical fluid extraction. The results of 24 full factorial experiment indicated that sf nanoparticles with particle size ps from 52. Request pdf nanoparticles synthesis using supercritical fluid technology towards biomedical applications supercritical fluid scf technology has become. Extraction supercritical fluid extraction, sfe from solid materials is the most developed application of supercritical fluid technology mainly for beverages coffee, tea, food ingredients hops and aromas, colourants, vitaminrich extracts, specific lipids and so on and nutra and phytopharmaceuticals. Supercritical fluid technology supercritical fluid technology has been widely used for various applications such as extraction, reaction, chromatography and material processing. Supercritical fluid synthesis and tribological applications of silver nanoparticledecorated graphene in engine oil nanofluid. Traditional freezedrying or spraydrying processes are often harmful to labile proteins and could be replaced by supercritical fluid scf drying to produce particles with defined physicochemical characteristics in a mild single step. Antioxidants free fulltext preparation and evaluation of.
Citescore values are based on citation counts in a given year e. Their formulation in dry form is often required to improve their stability. Applications for supercritical fluid technology production of special oils traditionally consumers have set their focus mainly in the convenience and taste of the oils. Selected for demonstration were antiinflammatory drugs ibuprofen and naproxen, for which co2 and co2cosolvent systems were used.
A proper formulation and particle size is essential to obtain high colorant activity. Supercritical fluid scf technology has become an important tool of materials processing in the last two decades. The invention discloses a process using supercritical liquid crystallization technology to prepare lornoxicam fine particles. Preparation and characterization of zro2 nanoparticles by. The various methods including the supercritical solution.
Stabilization of proteins in dry powder formulations using. The environmental and climate program demands technological solutions in the chemical industry that incorporate prevention of pollution. This unique combination process delivers a superior quality of omega3 concentrates the process starts with sfe, which involves using supercritical carbon dioxide sco2 to gently extract ethyl esters from unwanted elements such as glycerides, free. Pdf nanotechnology and supercritical fluids researchgate. Interest of the supercritical fluid technology for nanoparticles synthesis. The greatest requirement in the application of nanomaterials is its size and morphology control, which determine the application potential of the nanoparticles, as. Nanoparticles with supercritical fluids applied separations. In addition, close to the critical point, small changes in pressure or temperature result in large changes in density, allowing many properties of a supercritical. The resolv process produces exclusively nanoscale less than. Introduction design and fabrication of pharmaceutical particulate systems is still largely an art as opposed to a fundamental science. Ppt supercritical fluid powerpoint presentation free to. Supercritical fluid applications in the pharmaceutical. Microencapsulation and nanoencapsulation using supercritical.
A method of producing microparticles and nanoparticles of a solute via the extraction of solvent, having the solute dissolved therein, from an emulsion using a supercritical fluid. Supercritical fluid technology an overview sciencedirect topics. The greatest requirement in the application of nanomaterials is its size and morphology control, which determine the application potential of the nanoparticles, as their. The influences of operation parameters, including operation pressure and temperature, co2 total flow and ratio of co2 branch flow, on. Keywords drug delivery systems, nanotechnologies, supercritical fluids. Winner of the standing ovation award for best powerpoint templates from presentations magazine. In the pharmaceutical industry, this technique is applied to coat the solid dosage forms, liposome formulation, and reduction of particle size. The aim of the study was to develop and evaluate a new method for the production of micro and nanoparticles of poorly soluble drugs for drug delivery applications. The supercritical fluid technology can be considered as an extension of the usual synthesis routes, coupling advantages of the conventional methods with some additional inputs making it even more attractive.
Generation of silk fibroin nanoparticles via solution. Among them, supercritical fluid technology has been identified as potentially effective and applicable approach which has attracted increasing attention during recent years. The process can produce an aqueous suspension of particles that are substantially insoluble in water, and the solvents used in the process to form the emulsion initially can be recovered and recycled. Unlike the traditional methods used for the particle size reduction, supercritical fluid processing techniques offer advantages ranging from superior particle size control to clean processing. Nanoparticles in the pharmaceutical industry and the use of supercritical fluid technologies for nanoparticle production volume. Nanosizing drug particles in supercritical fluid processing. Overcoming multidrug resistance through inhalable sirna. Experimental study of nano particles formation through rapid. Masoud bahrami, sima ranjbarian, production of micro and nanocomposite particles by supercritical carbon dioxide, elsevier, the journal of supercritical fluids, vol. Oct 23, 20 stanipharm supercritical fluid technology and facilities for the development and manufacturing of active pharmaceutical ingredients. Applied separations can provide you with the means to make both organic and inorganic particles.
Supercritical co2 processes allow the design and control of particle size, as well as drug. Fine particles of model compounds cholesterol acetate ca, griseofulvin gf, and megestrol acetate ma were produced by extraction of the internal phase of oilinwater emulsions using supercritical. Recent the journal of supercritical fluids articles elsevier. Polymeric nanoparticles from rapid expansion of supercritical. Supercritical fluid technology scft offers exciting opportunities to produce and modify pharmaceutical substances and has the potential to. Supercritical fluid synthesis and tribological applications. Antioxidants free fulltext preparation and evaluation. The greatest requirement in the application of nanomaterials is its size and morphology control, which determine the. Lefler, glaxosmithkline abstract direct, visual observation of materials under supercritical conditions is an important first step in the development and refinement of supercritical fluid extraction, reaction, and. Therapeutic proteins have become essential in the treatment of many diseases. In addition, close to the critical point, small changes in pressure or temperature result in large changes in.
Therefore, the supercritical fluid technology has been investigated as an alternative to prepare biodegradable micro and nanoparticles because supercritical fluids are environmentally safe 21. Overcoming multidrug resistance through inhalable sirna nanoparticles decorated porous microparticles based on supercritical fluid technology peiyao xu, 1, 2 ranjith kumar kankala, 1, 2, 3 yujing pan, 1, 2 hui yuan, 1, 2 shibin wang, 1, 2, 3 and aizheng chen 1, 2, 3. Thermal decomposition and hydrothermal syntheses are but two ways to accomplish this. Application of supercritical fluid technology for preparation of drug. Formation of polymer nanoparticles in supercritical fluid jets. While process conditions require high pressures, technological advances have now made it feasible to acquire such equipment for the laboratory.
Hydrothermal synthesis of zirconia nanocrystals in supercritical water volume 19 issue 8 yukiya hakuta, tomotugu ohashi, hiromichi hayashi, kunio arai skip to main content accessibility help we use cookies to distinguish you from other users and to provide you with a better experience on our websites. Supercritical fluid technology for particle engineering ram b. Supercritical co 2 and h 2 o are extensively being used in the preparation. The particles are produced via the extraction of the solvent from the emulsion using the supercritical fluid. In general, the difficulties arising in the pharmaceutical industry are mostly owing to find a new method for development of novel drugs. Supercritical co 2 and h 2 o are extensively being used in the preparation of a great variety of nanomaterials.
This technique has several advantages such as avoid the use of solvents, particles are obtained as a dry powder, instead of suspensions, mild pressure and temperature. Supercritical fluid technology is one of the techniques applied in the formulation of several nanoparticles with the aid of supercritical co 2 and h 2 o. The solute to be precipitated is dissolved in the solvent to form a solution, and the solution is dispersed in an immiscible or partially miscible liquid to form an emulsion. In the last decade, the supercritical fluid scfassisted technology generation of micro or nano particles of organic, inorganic, or their composite compounds has attracted a growing interest for increasingly sophisticated applications among scientists in various fields. Supercritical fluid technology scft offers exciting opportunities to produce and modify. Micro and nanoparticles of carotenoids and biopolymers facundo mattea on. Supercritical carbon dioxide s co 2 is a fluid state of carbon dioxide where it is held at or above its critical temperature and critical pressure carbon dioxide usually behaves as a gas in air at standard temperature and pressure stp, or as a solid called dry ice when frozen. A search conducted using scifinder scholar returned 11 907 items dealing with supercritical. This method takes distinguishing properties of supercritical fluids to exhibit significant solvent strength when they are compressed to liquidlike densities. Cn101185868a technique for preparing lomoxicam ultra. However, a more systematic design and manufacture of parti.
Eckhard weidner and marcus petermann, preparation and processing of micro and nano scale materials by supercritical fluid technology, supercritical fluid extraction of nutraceuticals and bioactive compounds, 10. Micro and nano particles of carotenoids and biopolymers facundo mattea on. Hydrogen storage in graphene decorated with pd and pt nanoparticles using an electroless deposition technique. Supercritical fluid technology scft offers exciting opportunities to produce. Application of supercritical fluid technology for preparation.
Hydrothermal synthesis of zirconia nanocrystals in. A supercritical fluid is a substance with both gas and liquidlike properties. Liposome production by scco 2 processing as aforementioned, supercritical fluid technology is an interesting alternative for the production of safer and more stable drug delivery particles. Supercritical fluid technology is commonly utilized to prepared nanoparticles from drug solutions. Much research has been published about applications of supercritical fluid technology on the preparation of nanomaterials 1820.
Particle formation techniques using supercritical fluids. Supercritical fluids and in particular supercritical fluid carbon dioxide have shown to be a viable technology for a variety of extractions. An overview of pharmaceutical applications bhupinder singh sekhon. To overcome these drawbacks, the utilization of supercritical fluid is an alternative to produce these nanoparticles. Ppt supercritical fluid powerpoint presentation free.
By operating in the critical region, the pressure and temperature are used to regulate the fluid density, which, in turn, regulates the solvent power of a supercritical fluid. Conclusion in this work, ma particles were formed in nano scale through rapid expansion of supercritical co2 and with menthol as solid cosolvent. Composite nanoparticles using a supercritical fluid technology for enhanced oral and skin delivery eunsol ha 1, wooyong sim 1, seonkwang lee 1, jisu jeong 1, jeongsoo kim 2, inhwan baek 3, du hyung choi 4, heejun park 5, sungjoo hwang 6 and minsoo kim 1, 1 college of pharmacy, pusan national university, 63 busandaehakro, geumjeonggu. However, supercritical fluid scf technology presents a new and interesting route for particle formation, which avoids most of the drawbacks of the traditional methods. Its aim is to provide a focused platform for academic and industrial researchers to publish lasting scientific. Eckhard weidner and marcus petermann, preparation and processing of micro and nanoscale materials by supercritical fluid technology, supercritical fluid extraction of nutraceuticals and bioactive compounds, 10. Supercritical processes give micro or even nanoparticles with. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that. Nanoparticles of inorganic compounds can also be produced using supercritical fluids and subcritical fluids. Nanoparticles of poorly watersoluble drugs prepared by. The sce technology has been successfully applied at industrial scale for the. A simple search of the web site recently showed 92 books about supercritical fluids alone.
Supercritical fluid technology for particle engineering. Preparation and evaluation of resveratrolloaded composite nanoparticles using a supercritical fluid technology for enhanced oral and skin delivery by eunsol ha 1, wooyong sim 1, seonkwang lee 1, jisu jeong 1, jeongsoo kim 2, inhwan baek 3, du hyung choi 4, heejun park 5, sungjoo hwang 6 and minsoo kim 1. Improved supercapacitor performance of mno 2graphene composites constructed using a supercritical fluid and wrapped with an ionic liquid. Nanoparticles in the pharmaceutical industry and the use of. Supercritical fluid technology for drug nanoparticles youtube. Preparation and evaluation of resveratrolloaded composite. Formation of microparticles or nanoparticles with unique morphology is the most outstanding characteristic of particle formation from supercritical fluid technology. Supercritical fluid technology an overview sciencedirect. When the pressure and temperature of a substance is raised above its critical pressure and critical temperature the critical point the substance enters the supercritical state. Supercritical fluid technology for drug nanoparticles. Using supercritical fluid technology as a green alternative. If the temperature and pressure are both increased from stp to be at or above the critical point for. Experimental study of nano particles formation through.
Trends in particle formation of bioactive compounds using. Supercritical fluid scf technology is one such technique, which has become an important tool in the production of different particulate systems along with extraction and drying of protein and. Overcoming multidrug resistance through inhalable sirna nanoparticlesdecorated porous microparticles based on supercritical fluid technology peiyao xu, 1, 2 ranjith kumar kankala, 1, 2, 3 yujing pan, 1, 2 hui yuan, 1, 2 shibin wang, 1, 2, 3 and aizheng chen 1, 2, 3. Selected for demonstration were antiinflammatory drugs ibuprofen and naproxen, for which co 2 and co 2 cosolvent systems were used.
Much research has been published about applications of supercritical fluid technology on the preparation of nano materials 1820. Gupta department of chemical engineering, auburn university, auburn, alabama, u. Formation of polymer nanoparticles in supercritical fluid. Moreover, reducing precipitation pressure or increasing concentration. Nanoparticles synthesis using supercritical fluid technology. Carotenoid formulation is of great interest for the pharmaceutical and food industry. Various supercritical particle formation technologies are briefly described, including processes in which the supercritical fluid acts as a solute, solvent, and antisolvent. Major advances are needed to reduce the use of organic solvents, such as methanol, toluene, xylene, methyl ethyl ketone, and dichloromethane, which account for 27. It can effuse through solids like a gas, and dissolve materials like a liquid. Particle generation for pharmaceutical applications using. The materials such as nano and micro particles of high added value compounds. This technology precipitates micro14 as well as nanosized particles15 with large surface areas, controlled uniform particle sizes, and smooth surfaces,5b,14,16 which eventually augment drug bioavailability. Zro2 nanoparticles were successfully prepared by supercritical hydrolysis in two steps hydrolysis and dehydration and were characterized by xray diffraction xrd, scanning electron microscopy sem and laser particlesize analyzer. A supercritical fluid can be generally defined as a solvent at a temperature above its critical temperature, at which the fluid remains a single.
Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. The supercritical fluidprocessing technique, rapid expansion of a supercritical solution into a liquid solvent resolv, was applied to the nanosizing of waterinsoluble drug particles. The number of applications and technologies involving supercritical fluids has also grown explosively. Aerogels are materials with a high microporous structure, sometimes a nanoporous structure, both with a very low bulk density. The scfs advantages, benefits, and various preparation methods are discussed. Production of antibiotic micro and nanoparticles by supercritical antisolvent precipitation. Supercritical fluid applications in the pharmaceutical industry. The journal of supercritical fluids is an international journal devoted to the fundamental and applied aspects of pressurized substances and mixtures in the fluid state especially at conditions above the critical point including reactions, separations and chemical processes. Pratik sheth, harpreet sandhu, dharmendra singhal, waseem malick, navnit shah and m. Nanoparticles in the pharmaceutical industry and the use. Moreover, supercritical fluid technology is very attractive for manufacturing innovative therapeutic particles, either of pure active compounds or mixtures of excipient and active. Supercritical fluid technologies scft represent a recent approach for obtaining pharmaceutical materials in pure physical form and the application of supercritical fluids is a superior alternative to conventional precipitation and extraction processes. A supercritical fluid scf is any substance at a temperature and pressure above its critical point, where distinct liquid and gas phases do not exist. Supercritical fluid technology scft offers exciting opportunities to produce and modify pharmaceutical substances and has the.
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